Fetal anaemia from red blood cell membrane defect and co-inherited haemoglobin Constant Spring
نویسندگان
چکیده
منابع مشابه
The unusual pathobiology of hemoglobin constant spring red blood cells.
Hemoglobin Constant Spring (HbCS) is the most common nondeletional alpha-thalassemic mutation and is an important cause of HbH-like disease in Southeast Asia. HbCS variants have an almost normal mean cell volume (MCV) and the anemia is more severe when compared with other alpha-thalassemic variants. We explored the pathobiology of HbCS red blood cells (RBCs) because the underlying cause(s) of t...
متن کاملFetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia
The hydroxycarbamide (HC)-inducible small guanosine triphosphate (GTP)-binding protein, secretion-associated and RAS-related (SAR) protein has recently been shown to play a pivotal role in HBG induction and erythroid maturation by causing cell apoptosis and G1/S-phase arrest. Our preliminary analysis indicated that HC inducibility is transcriptionally regulated by elements within the SAR1A prom...
متن کاملInvestigation of membrane mechanics using spring networks: application to red-blood-cell modelling.
In recent years a number of red-blood-cell (RBC) models have been proposed using spring networks to represent the RBC membrane. Some results predicted by these models agree well with experimental measurements. However, the suitability of these membrane models has been questioned. The RBC membrane, like a continuum membrane, is mechanically isotropic throughout its surface, but the mechanical pr...
متن کاملPhosphorylation of the Red Blood Cell Membrane
The phosphorylation of red blood cell membrane fragments (RBCMF) during Ca ++ transport was investigated. When red cell membrane fragments are incubated with [y-a2P]ATP under the experimental condition which minimizes the phosphorylation of Na+-K+-ATPase, RBCMF are labeled in the presence of Mg ++ without Ca ++. When Ca ++ is added, the labeling decreases due to dephosphorylation of RBCMF. The ...
متن کاملThermoelasticity of red blood cell membrane.
The elastic properties of the human red blood cell membrane have been measured as functions of temperature. The area compressibility modulus and the elastic shear modulus, which together characterize the surface elastic behavior of the membrane, have been measured over the temperature range of 2-50 degrees C with micropipette aspiration of flaccid and osmotically swollen red cells. In addition,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ Case Reports
سال: 2015
ISSN: 1757-790X
DOI: 10.1136/bcr-2014-208196